منابع مشابه
Ischemia-Reperfusion Injury and Volatile Anesthetics
Ischemia-reperfusion injury (IRI) is induced as a result of reentry of the blood and oxygen to ischemic tissue. Antioxidant and some other drugs have protective effect on IRI. In many surgeries and clinical conditions IRI is counteract inevitable. Some anesthetic agents may have a protective role in this procedure. It is known that inhalational anesthetics possess protective effects against IRI...
متن کاملVolatile anesthetics and ischemia-reperfusion injury
(IR) injury can occur under various clinical conditions in which the restoration of blood and oxygen to ischemic tissues results in a massive release of oxygen free radicals. For example, cardiac surgery, stroke, tourniquet application for orthopedic surgery, organ transplantation, and restoration of shock can cause IR injury. Reperfusion produces an increased free radical concentration with li...
متن کاملUse of volatile anesthetics in extracorporeal circulation.
BACKGROUND AND OBJECTIVES The use of volatile anesthetics in cardiac surgery is not recent. Since the introduction of halothane in clinical practice, several cardiac surgery centers started to use these anesthetics constantly. CONTENT In the last years a great number of studies have shown that the volatile anesthetics have a protecting effect against myocardial ischemic dysfunction. Experimen...
متن کاملSodium Channels as Targets for Volatile Anesthetics
The molecular mechanisms of modern inhaled anesthetics are still poorly understood although they are widely used in clinical settings. Considerable evidence supports effects on membrane proteins including ligand- and voltage-gated ion channels of excitable cells. Na(+) channels are crucial to action potential initiation and propagation, and represent potential targets for volatile anesthetic ef...
متن کاملMechanisms of cardioprotection by volatile anesthetics.
A RAPIDLY growing body of evidence indicates that volatile anesthetics protect myocardium against reversible and irreversible ischemic injury. Identifying the mechanisms by which volatile agents mediate these antiischemic actions is the subject of intense research. This objective has been difficult to accomplish because volatile anesthetics also profoundly affect cardiovascular function. Volati...
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ژورنال
عنوان ژورنال: Immunological Investigations
سال: 2017
ISSN: 0882-0139,1532-4311
DOI: 10.1080/08820139.2017.1373905